Annals of Neurology, in press Amyloid-β Associated Cortical Thinning in Clinically Normal Elderly
نویسنده
چکیده
J. Alex Becker, PhD1, T. Hedden, PhD, J. Carmasin, BS, J. Maye, BS, D.M. Rentz, PsyD3,4, D. Putcha, BA2, B. Fischl, PhD1,2, D. Greve, PhD, G. Marshall, MD, S. Salloway, MD, D. Marks, MD, R.L. Buckner, PhD, R.A. Sperling, MD3,4 and K.A. Johnson, MD Department of Radiology, Massachusetts General Hospital, Harvard Medical School Athinioula A. Martinos Center for Biomedical Imaging Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School Department of Neurology, Massachusetts General Hospital, Harvard Medical School Department of Neurology, Warren Alpert Medical School, Brown University Memory and Aging Program, Butler University Tufts School of Medicine Department of Psychology and Center for Brain Science, Harvard University Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School Howard Hughes Medical Institute
منابع مشابه
Amyloid-β Associated Cortical Thinning in Clinically Normal Elderly
OBJECTIVE Both amyloid-β (Aβ) deposition and brain atrophy are associated with Alzheimer's disease (AD) and the disease process likely begins many years before symptoms appear. We sought to determine whether clinically normal (CN) older individuals with Aβ deposition revealed by positron emission tomography (PET) imaging using Pittsburgh Compound B (PiB) also have evidence of both cortical thic...
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Plasma levels of circulating amyloid-beta (Aβ) peptides are of particular interest in Alzheimer' disease, but little is known about cognitive and cortical correlates of peripheral Aβ levels in normal aging. Here, we compared cognitive functioning, vascular risk factors, and patterns of cortical thickness between cognitively intact elderly subjects with low (N = 60) and high (N = 60) plasma Aβ l...
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OBJECTIVE To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of neuropsychological tests. DESIGN Subjects underwent cognitive testing and PiB PET imaging (15 mCi for 90 minutes with an ECAT H...
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